Results: The main innovation that this study will provide to the literature is not only ionization but also the calculation of recoils, lateral scattering and phonon oscillation resulting from all interactions. This analysis was performed by using MC based TRIM simulation method of interactions. Materials and Methods: The main aim of this study is to analyze the LET, recoils, lateral scattering, and phonon energies of selected4He,7Li,8Be and10B heavy ions in the water phantom in the therapeutic energy range. Thanks to these unique properties of heavy ion radiotherapy, it can allow dose increase in tumors while reducing the radiation dose in adjacent normal tissues. This is a crucial step towards development of next-generation patient specific radiotherapy.īackground: The therapeutic usage of heavy ions has received much attention due to its advantageous physical and radiobiological assets compared to photon-based therapy. ![]() FRoG enables comparative analysis of different models for estimation of physical and biological effective dose in 3D within minutes and in excellent agreement with the gold standard Monte Carlo (MC) simulation. FRoG, Fast Recalculation on GPU, currently operates with four particle beams available at Heidelberg Ion Beam Therapy center, i.e., raster-scanning proton (1H), helium (4He), carbon (12C) and oxygen ions (16O). To this end, we engineered a unique graphics processing unit (GPU) based software architecture allowing rapid and robust dose calculation. Moreover, to overcome uncertainties of actual in-vivo physical dose distribution and biological effects elicited by different radiation qualities, development of a reliable high-throughput algorithm is required. To identify patients most benefiting from this technologically demanding therapy, fast assessment of comparative treatment plans utilizing different ion species is urgently needed. Radiotherapy with protons and heavier ions landmarks a novel era in the field of high-precision cancer therapy.
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